MagReSyn® Hydroxyl

Suitable as a nucleus for on-bead protein precipitation

MagReSyn® Hydroxyl, consists of hydroxyl terminated magnetic beads, suitable as a nucleus for applications such as on-bead protein precipitation. The hydrophilic surface and neutral functionality reduces non-specific interactions, increasing recovery of peptides after on-bead digestion of proteins.

Several publications have used our MagReSyn® beads as a nucleus for on bead precipitation, for clean-up of protein samples prior to digestion for mass-spectrometry. The ferromagnetic core ensures fast and efficient magnetic separation for the transfer of beads, particularly suitable for robotic automation of workflows on magnetic bead handling stations.

Although a variety of chemically functional beads have been used for this application, we would recommend MagReSyn® Hydroxyl to reduce potential carry over of contaminants, and better release of peptides after on-bead digestion for MS analysis.

Support: Proprietary polymer microparticles containing iron oxide (magnetite)
Bead size: ~5-10 µm
Formulation: 20 mg.ml^-1 suspension in 20% ethanol