Products supplied by ReSyn Biosciences (Pty) Ltd are for research purposes only. ReSyn products are not to be used for diagnostic, therapeutic or commercial purposes. Commercial means any use resulting in monetary gain, including, but not limited to, incorporation in a kit, repackaging and re-formulation. Please enquire about sub-licenses for commercial use.
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New miniaturized, high throughput technologies for bioseparation, diagnostics, DNA sequencing, flow cytometry, drug discovery, proteomics and genomics are in many instances reliant on attachment of functional biological molecules to a microsphere support. The vast array of life sciences applications include: capture reagents for immunoassay (fluorescence, enzyme linked etc); surfaces for immunoprecipitation; diagnostic assays; fluorescence microscopy; flow/imaging cytometry; magnetic cell separation; molecular diagnostics; agglutination tests; nucleic acid separation and protein separation among others. Conventional microsphere technologies use solid or porous/cracked microspheres with binding of biological molecules limited to the surface, a key factor constraining performance and the development of new applications for microsphere technologies and products. We have developed a novel (patented) microsphere technology platform, comprising a hyper-porous polymer matrix that allows penetration of biological and synthetic molecules throughout the volume of the microspheres. This offers exceptionally high surface area for binding of molecules and allows performance that is orders of magnitude greater than alternate technologies. The binding capacity serves as a major performance contributor to the number of applications and versatility for end-user applications by and further enables miniaturization, increased sensitivity and reducing the cost of R&D.
Technology Description
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Intellectual Property
ReSyn Biosciences has an exclusive license to the proprietary polymer microsphere technology developed and patented at the CSIR (WO2009057049; EP2205662; US201314973; JP5442624; CN101874061; CA2703478). ReSyn Biosciences (Pty) Ltd is a biotechnology company founded by the technology inventors.
ReSyn Technology
ReSyn Technology Performance Superiority
Why choose ReSyn? Demonstrated performance superiority Technology flexibility allows a range of unique solutions to meet your requirements Readily integrated into existing workflows Technical advantages of ReSyn for bioseparation: High biomolecule binding capacity (enables miniaturization and high-throughput processes) High functional group density of 3500 µmoles.g-1 vs 300-600 µmoles.g-1 for competitor technologies, allows for multi-point covalent attachment of bioseparation ligand reducing leaching and enhancing stability. Improved biomolecule purity and recovery
Technical advantages of ReSyn for biomolecule immobilization: High protein binding capacity (>100% protein loading) Enhanced protein stability through multipoint attachment Demonstrated enzyme activity retention Co-immobilization of multiple enzymes Immobilization of multimeric enzymes
Unique features of MagReSyn® microspheres: Resistant to oxidation o Increased stability and shelf-life o Reduced sample contamination o Improved reproducibility Rapid recovery by magnetization (<10 sec) o Improved research efficiency o Reduced experimental time o High throughput automation compatible o Reduced protocol times
MagReSyn® MagReSyn® Competitor Competitor Competitor MagReSyn® 3 seconds 10 seconds 30 seconds Confocal microscope images of microsphere cross-sections showing the degree of penetration of fluorescently labelled BSA onto solid, cracked and ReSyn micropsheres (left to right). ReSyn microspheres allow penetration of biomolecules throughout the volume of the microsphere as opposed to surface-based attachment.   Solid microsphere Cracked microsphere ReSyn microsphere