Products supplied by ReSyn Biosciences (Pty) Ltd are for research purposes only. ReSyn products are not to be used for diagnostic, therapeutic or commercial purposes. Commercial means any use resulting in monetary gain, including, but not limited to, incorporation in a kit, repackaging and re-formulation. Please enquire about sub-licenses for commercial use.
Support: Proprietary polymer microspheres containing iron oxide (magnetite) Binding capacity: > 10 µg phosphopeptide per mg support Bead size: 5-10 µm average Formulation: 25 mg.ml-1 suspension in 20% ethanol
TiO2-functional microspheres for highly-specific phosphopeptide enrichment
MagReSyn® TiO2 Performance Superiority
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Comparative assessment of MagReSyn® TiO2  (green bars) vs a leading competitor (orange bars) for phosphopeptide enrichment. 32P labelled CHK1 tryptic digests were enriched for phosphopeptides and analyzed by LC/MS/MS. MagReSyn® TiO2  showed exceptional specificity with up to 100% of identified peptides being phosphorylated, vs 78% for the competitor. Phosphopeptide recovery was 78% using MagReSyn® TiO2 and 70% using competitor TiO2. Refer to Application Note above.
Protein phosphorylation plays a pivotal role in most cellular processes, with 30% of the proteome transiently phosphorylated. It is therefore a widely studied post-translational modification. However, the low-abundant nature of phosphopeptides, the low stoichiometry of the modification, and the physico-chemical properties of phosphorylated peptides make proteome-wide characterization of phosphorylation a significant challenge to proteomics researchers. Consequently, technologies than can specifically enrich phosphopeptides, and are compatible with mass spectrometric analyses, are highly desirable. MagReSyn® TiO2 microspheres allow highly specific, reproducible enrichment of phosphopeptides from complex biological samples such as protein digests. Titanium dioxide enrichment shows selective affinity for phosphoserine (pSer), phosphothreonine (pThr) and phosphotyrosine (pTyr) residues. MagReSyn® TiO2 microspheres have been engineered to achieve the ultimate specificity, outperforming competitor products, with excellent phosphopeptide recovery.  MagReSyn® TiO2  microspheres may be used alone or in combination with MagReSyn® ZrO2 and/or MagReSyn® Ti-IMAC microspheres to enrich diverse types of phosphopeptides for comprehensive phosphproteomics analyses.
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Click HERE for literature on Reproducible Automated Phosphopeptide Enrichment using MagReSyn® TiO2
MagReSyn® TiO2 
TiO2
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