Multi-mode HILIC microparticles for sample clean-up pre-Mass Spectrometry

The range of possible sample contaminants, variability in starting material, & range of possible reagents for sample preparation has resulted in variability in data generated from mass spectrometry. Current methodologies and tools for sample clean-up prior to digestion and MS analysis require the use of in-line column chromatography, desalting columns/membranes, and/or packed tips for partitioning. Although some of these techniques are broadly applicable, they are not routinely automatable, or don’t provide the option for parallel processing required for high-throughput. In order to fully automate clean-up we have developed a versatile magnetic mixed-mode HILIC with broad applicability for the removal of common contaminants required in the solubilization and denaturation of proteins. The automation of sample processing using magnetic beads reduces sample handling, and providing massively parallel sample processing, and improves reproducibility.

MagReSyn® HILIC provides a highly reproducible and fully automatable solution for parallel protein sample clean-up prior to MS analysis. The product is compatible with a range of common contaminants which interfere in the generation of high quality data from MS analysis of samples. 

Please review our extensive range of application notes and posters to see how MagReSyn® HILIC can be used for your sample preparation. 

Support: Proprietary polymer microspheres containing iron oxide (magnetite)
Bead size: ~5-10 µm
Formulation: 20 suspension in 20% ethanol


Product Resources

Citation and Reference Examples

Please review our comprehensive method library to find the most relevant reference material for your particular application.

Dysregulated healing responses in diabetic wounds occur in the early stages postinjury

–  Kiara Boodhoo et al.

Journal of Molecular Endocrinology (2021)


Effect of polyethylene glycol 20 000 on protein extraction efficiency of formalin-fixed paraffin-embedded tissues in South Africa

–  Sophia Rossouw et al.

AJLM (2021)


A Label-Free Proteomic and Complementary Metabolomic Analysis of Leaves of the Resurrection Plant Xerophyta schlechteri during Dehydration

–  H Gabier et al.

Life (2021)


Evaluation of Protein Purification Techniques and Effects of Storage Duration on LC-MS/MS Analysis of Archived FFPE Human CRC Tissues

–  Sophia C. Rossouw et al.

Pathology and Oncology Research (2021)


Proteomic analysis of three medically important Nigerian Naja (Naja haje, Naja katiensis and Naja nigricollis) snake venoms

–  Fatima Amin Adamude et al.

Toxicon (2021)


SWATH-MS based proteomic profiling of pancreatic ductal adenocarcinoma tumours reveals the interplay between the extracellular matrix and related intracellular pathways

–  Ekene Emmanuel Nweke et al.

PLOS ONE (2020)


Products supplied by ReSyn Biosciences (Pty) Ltd are for research purposes only. ReSyn products are not to be used for diagnostic, therapeutic or commercial means any use resulting in monetary gain, including, but not limited to, incorporation in a kit, repackaging and re-formulation. Please enquire about sub-licenses for commercial use.